Endocrine Abstracts

Insulin pump is one of the treatment options for patients with type 1 diabetes mellitus. In July 2008, NICE has issued Technological Appraisal (TA 151) regarding insulin pump therapy guidance.Objective of the audit: To measure current practice in Colchester General Hospital in continuous subcutaneous insulin infusion – CSII (insulin pump) for the treatment of diabetes mellitus against the recommendations in the technological appraisal (TA 151).<...

An 85-year-old lady presented to hospital with fast atrial fibrillation and had some signs of pulmonary congestion. Her admission blood tests were normal apart from a raised urea. Her liver function tests on admission were normal (AST 26 ALP 99). Thyroid function tests showed that she was thyrotoxic with fT4 42 and TSH<0.03. Her TPO antibodies were negative. She was started on carbimazole 20 mg od.Repeat liver function tests showed that her GGT and a...

Controversy about the optimal dose of 131I in thyrotoxicosis is ongoing. High doses result in higher cure rates, but are associated with elevated risk of hypothyroidism and irradiation exposure. There is no consensus as to the optimum period of thionamide discontinuation prior to treatment, nor to its impact on the success of RAI.We retrospectively analysed 151 clinical records of patients with thyrotoxicosis due to Grave’s disease or tox...

A 51 year old female patient presented in 2000 with a 7 month history of diarrhoea and weight loss. Bloods revealed hypokalaemia (1.9). Infection and malabsorption screen negative, but patient remained hypokalaemic despite maximum iv and oral replacement. No abnormality was found endoscopically. Fasting gut hormone profile showed raised Vasoactive Intestinal Polypeptide (VIP) >400 (NR <30). CT scan confirmed 5cm mass in body of pancreas, no metastatic disease. Response...

Background: Phaeochromocytomas and paragangliomas are familial in up to 25% of cases and can result from succinate dehydrogenase (SDH) gene mutations.Objective: To describe the clinical manifestations of subjects with SDH-B gene mutations.Design: Retrospective case series.Patients: Thirty-two subjects with SDH-B gene mutations followed-up between 1975 and 2007. Mean follow-up of 5.8 years (S.D....